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Nano & Neuro-genetic Research center

Nano & Neuro-genetic Institute is responsible for clinical applications using nanotechnology for the related areas of the brain and nervous system disorders, and identifying disease-susceptibility genes for neurological diseases and for neuropharmacogenetics research.



• Director of Researcher Center: Keun-A Chang, Ph.D.

Assistant Professor, Department of Pharmacology
Hambakmoeiro 191, Yeonsu-gu, Incheon city, 406-799, Korea
Tel: +82-32-820-4332
Fax: +82-32-820-4744
E-mail: keuna705@gachon.ac.kr





• Education:

Mar.2000–Feb.2004 Ph.D. Department of Pharmacology, College of Medicine Seoul National University, Seoul, Korea Advisor: Yoo-Hun Suh
Mar.1997–Feb.1999 M.S. Department of Pharmacology, College of Medicine Seoul National University, Seoul, Korea Advisor: Yoo-Hun Suh
Mar.1993–Feb.1997 B.S. Department of Chemistry, College of Natural Science, Kyung-Pook University, Daegu, Korea


• Professional Experiences:

Sep.2012–present Assistant Professor, Dept. of Pharmacol., Coll. of Med., Gachon University
Mar.2009–Aug.2012 Senior Research Fellow Neurosci Res. Inst., Seoul National Univ.
Mar.2008–Feb.2009 Professor extraordinary, University of Seoul
Sep.2007–Feb.2008 esearch Fellow Neurosci Res. Inst., Seoul National Univ.
Mar.2004–Aug.2007 ostdoctoral Fellow Department of Pharmacology, College of Medicine, & National Creative Research Initiative Centre for Alzheimer's Dementia, Seoul National University
Advisor: Yoo-Hun Suh
Feb.2004–Apr.2004 Visiting Student, Babraham Institute, UK
Sep.2003–Dec.2003 Visiting Student, Stem cell Institute, University of Queensland, Australia


• Publications(SCI):

1 Chang KA, Kim HJ, Ha TY, Kim J, Ha S, Shin KY, Moon C, Nacken W, Kim HS, Suh YH. (2014) S100A9 Knockout Decreases the Memory Impairment and Neuropathology in Crossbreed Mice of Tg2576 and S100A9 Knockout Mice Model. PLoS One. 2014 Feb 25;9(2):e88924.
2 Ha S, Ahn S, Kim S, Joo Y, Chong YH, Suh YH, Chang KA. (2014) In vivo imaging of human adipose-derived stem cells in Alzheimer's disease animal model. J Biomed Opt. 2014 May;19(5):051206.
3 Chang KA, Kim HJ, Joo Y, Ha S, Suh YH. (2014) The therapeutic effects of human adipose-derived stem cells in Alzheimer's disease mouse models Neurodegener Dis. 2014;13(2-3):99-102.
4 Lee EO, Yang JH, Chang KA, Suh YH, Chong YH. (2013) Amyloid-β peptide-induced extracellular S100A9 depletion is associated with decrease of antimicrobial peptide activity in human THP-1 monocytes. J Neuroinflammation.10:68
5 Chang KA, Kim S, Kim JA, Park HG, Ra JC, Kim HS, Suh YH. (2012) The preventive and therapeutic effects of intravenous human adipose-derived stem cells in Alzheimer's disease mice. PloS One. 7(9)
6 Chang KA, Kim JA, Kim S, Joo Y, Shin KY, Kim S, Kim HS, Suh YH. (2012) Therapeutic potentials of neural stem cells treated with fluoxetine in Alzheimer's disease. Neurochem Int. 61(6):3.
7 Chang KA, Kim HJ, Suh YH. (2012) The Role of S100a9 in the Pathogenesis of Alzheimer's Disease: The Therapeutic Effects of S100a9 Knockdown or Knockout. Neurodegener Dis. 10(1-4):27-9.
8 Hong BH, Ha S, Joo Y, Kim JA, Chang KA, Woo RS, Suh YH, Kim JH, Kim HS. (2012) Amyloid precursor protein binding protein-1 knockdown reduces neuronal differentiation in fetal neural stem cells. Neuroreport. 23(2):61-6.
9 Chang KA, Kim JW, Kim JA, Lee SE, Kim S, Suh WH, Kim HS, Kwon S, Kim SJ, Suh YH. (2011) Biphasic electrical currents stimulation promotes both proliferation and differentiation of fetal neural stem cells. PLoS One. 6(5)
10 Joo Y, Ha S, Hong BH, Kim J, Chang KA, Liew H, Kim S, Sun W, Kim JH, Chong YH, Suh YH, Kim HS. (2011) Amyloid precursor protein binding protein-1 modulates cell cycle progression in fetal neural stem cells. PLoS One. 5(12)
11 Chang KA, Suh YH (2010) Possible roles of amyloid intracellular domain of amyloid precursor protein. BMB Rep. 43(10):656-63
12 Chang KA, Ha TY, Kim J, Kim HS, Kim S, Chong YH, Suh YH. (2010) S100a9 knockdown decreases the memory impairment and the neuropathology in Tg2576 mice, AD animal model. PLoS One. 5(1)
13 KY Shin, JY L, BY Won, HY Jung, KA Chang, S Koppula, YH Suh (2009) BT-11 is effective for enhancing cognitive functions in the elderly humans. Neurosci Lett. 465(2):157-9
14 Kim S, Cho SH, Kim KY, Shin KY, Kim HS, Park CH, Chang KA, Lee SH, Cho D, Suh YH. (2009) Alpha-synuclein induces migration of BV-2 microglial cells by up-regulation of CD44 and MT1-MMP. J Neurochem. 109(5):1483-96
15 J Ma, Y Wang, J Yang, M Yang, K-A Chang, L Zhang, F Jiang, Y Li, Z Zhang, C Heo and Y-H Suh (2007) Treatment of hypoxic-ischemic encephalopathy in mouse by transplantation of embryonic stem cell-derived cells. Neurochemistry International. 51(1):57-65.
16 Choi Y, Kim HS, Shin KY, Kim EM, Kim M, Kim HS, Park CH, Jeong YH, Yoo J, Lee JP, Chang KA, Kim S, Suh YH. (2007) Minocycline Attenuates Neuronal Cell Death and Improves Cognitive Impairment in Alzheimer's Disease Models. Neuropsychopharmacology. 32(11):2393-404.
17 K-A Chang, C Heo, HS Choi, H-S Kim, S Kim, H Liew, JA Kim, E Yu, J Ma and Y-H Suh (2007) Effects of the monomeric, oligomeric and fibrillar A42 peptides on the proliferation and differentiation of adult neural stem cells from SVZ. J Neurochem. 102(2):493-500.
18 Y Xu, H-S Kim, Y Joo, Y-R Choi, K-A Chang, C H Park, K-Y Shin, S Kim, Y-H Cheon, T-K Baik, J-H Kim and Y-H Suh. (2007) Intracellular Domains of Amyloid Precursor-Like Protein 2 Interact with CP2 Transcription Factor in the Nucleus and Induce Glycogen Synthase Kinase-3Expression. Cell Death Differ. 14(1):79-91.
19 KA Chang, HS Kim, TY Ha, JW Ha, KY Shin, YH Jeong, JP Lee, CH Park, S Kim, TK Baik and YH Suh. (2006) Phosphorylation of APP at Thr668 regulates the nuclear translocation of AICD and induces neurodegeneration. Mol Cell Biol. 26(11):4327-38.
20 Jeong SJ, Kim M, Chang KA, Kim HS, Park CH, Suh YH. (2006) Huntingtin is localized in the nucleus during preimplanatation embryo development in mice. Int J Dev Neurosci. 24(1):81-5.
21 Joo Y, Kim HS, Woo RS, Park CH, Shin KY, Lee JP, Chang KA, Kim S, Suh YH (2006) Mefenamic acid Shows Neuroprotective Effects and Improves Cognitive Impairment in in vitro and in vivo Alzheimer's Disease Models. Mol Pharmacol. 69(1):76-84.
22 Chang KA, Suh YH. (2005) Pathophysiological roles of amyloidogenic carboxy-terminal fragments of the beta-amyloid precursor protein in Alzheimer's disease. J Pharmacol Sci. 97(4):461-71. Review.
23 Kim HS, Kim EM, Kim NJ, Chang KA, Choi Y, Ahn KW, Lee JH, Kim S, Park CH, Suh YH (2004) Inhibition of histone deacetylation enhances the neurotoxicity induced by the c-terminal fragments of amyloid precursor protein. J. Neurosci. Res. 75(1):117-24.
24 Kim HS, Kim EM, Lee JP, Park CH, Kim S, Seo JH, Chang KA, Yu E, Jeong SJ, Chong YH, Suh YH (2003) C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression. FASEB J. 17(13):1951-3.
25 Lee Y, Chang DJ, Lee YS, Chang KA, Kim H, Yoon JS, Lee S, Suh YH, Kaang BK. (2003) -Amyloid Peptide Binding Protein is not coupled to G protein in heterologous Xenopus expression system. J. Neurosci. Res., 73(2):255-9.
26 1. HS Kim, CH Park, S Kim, SJ Jeong, M Lee, JH Seo, SH Choi, KA Chang, EM Kim and YH Suh (2002) Molecular pathogenesis of Alzheimer's disease : amyloid precursor protein, A, C-terminal fragments of APP and Tau. Experimental Neurobiology, 11:71-89.
27 JH Kim, JC Rah, SP Fraser, KA Chang, MBA Djamgoz and YH Suh (2002) Carboxyl terminal peptide of β-amyloid precursor protein blocks IP3-sensitive Ca2+ release in Xenopus laevis oocytes. J. Biol. Chem. 277(23):20256-63.
28 HS Kim, JH Lee, JP Lee, EM Kim, KA Chang, SJ Jeong, MC Wittendorp, CH Park, SH Choi, JH Seo, and YH Suh (2002) Amyloid β peptide induces cytochrome C release from mitochondria; A possible neurotoxic mechanism of intracellular Aβ. Neuroreport. 13:1989-1993.
29 YH Suh, JH Seo, YX, C Heo, L Kim, JH Choi, SH Choi, JC Rah, KA Chang, WH Suh. (2002) Toxicity of APP Fragments. Mapping the Progress of Alzheimers Parkinsons Disease Kluwer Academic/Plenum Publishers.
30 JH Seo, SH Kim, HS Kim, CH Park, SJ Jeong, JH Lee, SH Choi, KA Chang, JC Rah, JW Koo, EM Kim and YH Suh. (2001) Effects of Nicotine on APP Secretion and A - or CT105-Induced Toxicity. Biol. Psychiatry 49: 240-247.
31 YH Suh, HS Kim, CH Park, JH Seo, JP Lee, SJ Jeong, SS Kim, JH Lee, SH Choi, KA Chang, JC Rah, SS Kim. (2001) Etiological roles of Aβand carboxyl terminal peptide fragments of amyloid precursor protein in Alzheimer disease. Neuroscientific Basis of Dementia, 217-224.
32 SJ Jeong, HS Kim, KA Chang, DH Geum, CH Park, JH Seo, JC Rah, JH Lee, SH Choi, SG Lee, K Kim, and YH Suh. (2000) Subcellular localization of presenilins during mouse preimplantation development. FASEB J. 14(14):2171-2176.
33 CH Park, SH Choi, Y Piao, SH Kim, HS Kim, SJ Jeong, JC Rah, JH Seo, JH Lee, KA Chang, YJ Jung, and YH Suh. (2000) Glutamate and aspartate impair memory retention and damage hypothalamic neurons in adult mice. Toxicology Letters 115(2): 117-125.
34 KA Chang, JP Lee, HS Kim, SS Kim, SJ Jeong, and YH Suh (2000) APP Carboxyl-Terminal Fragment Without or With Aβ Domain Equally Induces Cytotoxicity in Differentiated PC12 Cells and Cortical Neurons. J Neurosci. Res. 60: (4) 565-570.
35 KA Chang, SH Kim, HS Kim, Y. Sakaki, CW Park, and YH Suh (1999) Inhibition of the NGF and IL-1β-Induced Expression of Alzheimer's Amyloid Precursor Protein by Antisense Oligonucleotides. J. Molecular Neuroscience 12: 69-74.


Publications (non SCI):

1 HS Kim, CH Park, S Kim, SJ Jeong, M Lee, JH Seo, SH Choi, KA Chang, EM Kim, YH Suh (2002) Molecular Pathogensis of Alzheimer's disease: Amyloid Precursor Protein, Aβ, C-Terminal Fragments of APP and Tau. Experimental Neurobiology 11:71-89.
2 JH Seo, KA Chang, HS Kim, CH Park, SH Kim, MJ Lee, SJ Jeong, SH Choi, JC Rah, JW Koo, EM Kim, YJ Xu, JH Choi, JK Shin, CJ Huh, LJ Kim, YH Suh (2001) Effects of Nicotine on Aβ or CT105-induced Toxicity J Korean Brain Soc. 1(1): 77-84.
3 SJ Jeong, HS Cho, YH Chong, YJ Lee, HS. Kim, SS. Kim, CH. Park, SH. Kim, YM Choi, YK Kim, JH. Choi, K Jang, J Ma, YH An, CW Park, KW Lee, K Kim, and YH Suh (1997) Expression of Alzheimer's Amyloid Precursor Protein(βAPP) in the Brain of Senescence Accelerated Mouse(SAM) Korean J. Gerontol. 7: 90-9


Patents:

1 S100a9의 발현을 억제하는 shRNA를 포함하는 치매 치료용 약학 조성물. 2010.5.31
application number: 10-2010-0050864 (Korea)
2 Pharmaceutical composition for treating dementia comprising shRNA inhibiting S100a9 expression. 2010.8.5number: 12/851,273 (USA)


wards and Scholarship:

Oct. 2003 A Chung-Buk governor citation for 2002 Osong international Bio-Expo
Oct. 2006 ChoongWae Prize, Korean Society of Pharmacology
Feb. 2001 Brain Korea 21 Scholarships, Ministry of Education
Oct. 2000 Outstanding Research Award, CRI Program, Ministry of Sci. & Tech
Aug. 2000 Brain Korea 21 Scholarship, Ministry of Education
Mar. 1998 Research Assistant Scholarship, Coll. of Med., Seoul National Univ.


Young scientist fellowship from Conference:

2011 10th International Conference AD/PD
2009 12th International Conference on Alzheimer's Disease and Related Disorders
2007 21th International Society for Neurochemistry
2006 7th Biennial Meeting of APSN
2005 20th International Society for Neurochemistry
2004 6th Asian Pacific Society for Neuroscience
2003 5th International Brain Research Organization
2002 8th International Conference on Alzheimer's Disease and Related Disorders
2000 7th International Conference on Alzheimer's Disease and Related Disorders


Professional Memberships:

International Member of Society for Neuroscience
Asian Pacific Society of Neurochemistry
Korean Society of Pharmacology
Korean Society for Neurosciences