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Research Center of Cerebrovascular Disease

• Objectives:

1. Developing diagnostic techniques and microvascular imaging techniques using ultra-high-field 7T MRI to contribute for
    the early diagnosis of stroke and the development of new treatment strategy.
2. Developing three-dimensional microvascular segmentation technique for the quantitative analysis of cerebrovascular
    disease.
3. Developing application of multi-modal fusion system such as PET- MRI for the potential relevance of early detection of
    neurological disorders



• Director: Yeong-Bae Lee, MD., PhD.

Gachon University Gil Medical Center
Medical department : Neurology
Position : Professor
Detailed specialty : Stroke Headache, Dizziness, Vascular Dementia
Homepage : http://blog.naver.com/nryblee



• Educational Background:

2003-2006 Ph.D. Degree from Hanyang University Graduate School(www.sgs.hanyang.ac.kr) Seoul, South Korea (mentor, Seung Hyun Kim) ; Role of GSK-3βActivity in Motor Neuronal Cell Death induced by G93A or A4V mutant hSOD1 Gene.
1996-2001 Master Degree from Hanyang University Graduate School(www.sgs.hanyang.ac.kr) Seoul, South Korea (mentor, Ju Han Kim) ;The Effect of Whole Body Irradiation for the Treatment of Myasthenia Gravis.
1987-1992 M.D. Degree from College of Medicine, Hanyang University (www.hanyang.ac.kr) Seoul, South Korea.


• Career:

2014.3 - Director Cerebrovascular Disease Research Center, Neuroscience Research Institute
2014.1 - Director Research Planning and Coordination, Neuroscience Research Institute
2014-2015 Interantional Stroke Conference(ISC) Abstract Reviewer, American Stroke Association(ASA)
2013.5- Director International Cooperation Center, Gachon University, School of Medicine
2013.4- Director Gachon Brain Health Center
2012.5-2013.9 Planning Vice director, Gachon University Gil Medical Center
2011.4- Professor Department of Neurology, Gachon University of Medicine and Science (www.gachon.ac.kr),
Gil Medical Center(www.gilhospital.com), Incheon-city, Gyeonggi-do, South Korea
2010.8- Vice Head of Stroke Unit
2006-2011.3 Associate Professor Department of Neurology, Gachon University of Medicine and Science (www.gachon.ac.kr), Gil Medical Center(www.gilhospital.com), Incheon-city, Gyeonggi-do,
South Korea
2002-2005 Assistant Professor Department of Neurology, Gachon University of Medicine and Science (www.gachon.ac.kr), Gil Medical Center(www.gilhospital.com)
2001 Instructor Department of Neurology, Gachon University of Medicine and Science (www.gachon.ac.kr), Gil Medical Center(www.gilhospital.com)
1998-2000 Public Health Doctor (military service) in Anseong Medical Center Anseong-city, Gyeonggi-do, South Korea
1994-1997 Resident in Neurology, Hanyang University Medical Center, Seoul, South Korea
1993 Intern in Hanyang University Medical Center, Seoul, South Korea


• Membership:

Korean Neurological Association
Korean Stroke Association
International Stroke Society
World Federation of Neurology
The Korean Society for Clinical Neurophysiology
Korean Dementia Association
Korean Headache Association
Korean Epilepsy Society
Korean Medical Association
Korean Study Group for Multiple Sclerosis and Other Demyelinating Diseases
Korean Society for Neurodegenerative Disease



• Major Activities:

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A noninvasive technique for visualization of microvessels in asymptomatic patients with middle cerebral artery steno-occlusion. Vascular Medicine 2013;18(5):314-317
Pictorial Review of In Vivo Human Brain : From Anatomy to Molecular Imaging. World Neurosurgery 2012,S1878-8750(12)01194-1
Relation between Left Atrial Enlargement and Stroke Subtypes in Acute Ischemic Stroke Patients. Journal of cerebrovascular and endovascular neurosurgery 2013. Sep;15(3):131-6.
Vertebrobasilar Occlusion Presenting as Sudden Isolated Bilateral Sensorineural Hearing Loss : Case Report. Journal of cerebrovascular and endovascular neurosurgery 2013. Sep; 15(3):225-8.
Distal Subclavian Artery Occlusion Causing Multiple Cerebral Infarcts. Consequence of Retrograde Flow of a Thrombus? Journal of cerebrovascular and endovascular neurosurgery 2013. Sep;15(3):221-4.
Microvascular imaging of asymptomatic MCA steno-occlusive patients using ultra-high-field 7T MRI. J Neurol 2013;260:144-150
Evolution of abnormal eye movements in Wernicke's encephalopathy: Correlation with serial MRI findings. Journal of the Neurological Sciences 2012;323(1-2):77-79
Gene-smoking interaction on ischemic stroke:case-control study of glutathione S-transferase polymorphism. Korean J Stroke 2012;14(2):67-73
A case of cluster headache accompanied by myoclonus and hemiparesis. Journal of Clinical Neurology 2012;8(1):1-4
Three dimensional model-based analysis of the lenticulostriate arteries and identification of the vessels correlated to the infarct area: preliminary results. Int J Stroke 2011 Oct 6
Serum S100 protein as a marker of ischemic stroke severity during hyperacute stage. Kor J Cerebrovascular Surgery 2011;13(3):239-243
Neurosyphilis presenting with unilateral tonic pupil. J Korean Neurol Assoc . 2011;29(3):274-275
Etiologic Study of Tarsal Tunnel Syndrome by Operative and MRI findings. J Korean Society for Clinical Neurophysiology. 2011,13(2);87-92
Electrophysiologic characteristics of combined idiopathic carpal tunnel syndrome and tarsal tunnel syndrome. J Korean Society for Clinical Neurophysiology 2011;13(1):31-7
Effects of disability type and exercise participation on upper extremity function among disabled male workers . International SportMed Journal 2010;11(4):398-410
A Case of Guillain-Barre Syndrome Complicated with Reversible Cardiomyopathy. J Korean Society for Clinical Neurophysiology 2010;12(2):59-63
A Case of Action-Induced Clonus that Mimicked Action Tremors and was Associated with Cervical Schwannoma. Journal of Movement Disorders 2010;3(2):48-50
Study on sleep problems by using scale in patients complaining on headache on out patient basis. Journal of Korean Sleep Society 2010;7(1):8-14
A case of spontaneous intracranial hypotension with subdural hematoma mimicking meningitis. Kor J Cerebrovascular Surgery 2010;12(3):156-158
Pure Retrograde Amnesia: Is this real organic or psychogenic? J Korean Neurol Assoc . 2010;28(3):225-229
Bio-Printing of Collagen and VEGF-releasing Fibrin Gel Scaffolds for Neural Stem Cell Culture. Experimental Neurology. 2010 ;223(2):645-652
Lenticulostriate arteries in chronic stroke patients visualized by 7T magnetic resonance angiography. International Journal of Stroke. 2010;5(5):374-380
Midbrain atrophy in subcortical ischemic vascular dementia. Journal of Neurology. 2009;256(12):1997-2002
The prevalence of a low response to aspirin and its association with recurrent ischemic cerebrovascular events. Korean Journal of Cerebrovascular Surgery. 2009;11(4):161-166
Clinical features, disability and socioeconomic status of patients with muscular dystrophy in korea. J Korean Neurol Assoc . 2009;27(4):320-331.
Prediction of clinical outcomes in patients with acute ischemic stroke by measurements of motor evoked potentials. Kor J Cerebrovascular Surgery . 2009;11(4):154-160
Chorea in the both lower limbs associated with nonketotic hyperglycemia. Journal of Movement Disorders. 2009;2(2):98-100
Preliminary Study About Effect of Continuous Positive Airway Pressure on Cardiac Autonomic Imbalance in Obstructive Sleep Apnea Syndrome. J Korean Neurol Assoc . 2009;27(2):136-141
Exploding Head Syndrome. J Korean Neurol Assoc . 2009;27(2):170-173
Novel compound heterzygous mutations the pantothenate kinase 2 gene in a korean parient with atypical pantothenate kinase associated neurodegeneration. Journal of Movement Disorders . 2009;2(1):45-47.
Characteristics of dizziness in supratentorial infarctions. J Korean Neurol Assoc . 2009;27(1):7-12
Comparing Sleep Questionnaires and Respiratory Disturbance Index in Obstructive Sleep Apnea Syndrome Patients. Journal of Korean Sleep Society . 2008;5:89-93
Dissociation of Hangul and Hanja Reading after Left Parieto-occipital Infarction. J Korean Neurol Assoc . 2008;26(4):361-364
Correlation of Serum Total Bilirubin Levels and the Severity of Acute Ischemic Stroke. Kor J Cerebrovascular Surgery . 2008;10(3):442-447
A case of chorea as the inital manifestation of SLE triggered by estrogen. Journal of Movement Disorders . 2008;1(2):86-89
Dementia mimicking a sudden cognitive and behavioral change induced by left globus pallidus infarction: Review of two cases. JOURNAL OF THE NEUROLOGICAL SCIENCES. 2008;15(272):178-182
YH Hong, SB Kwon, BJ Kim1, BJ Kim2, SH Kim, JK Kim, KS Park, JJ Sung, EH Sohn, YB Lee, DS Jeong, BO Choi, YC Choi, IS Joo. Prognosis of ocular myasthenia in Korea: A retrospective multicenter analysis of 202 patients. Journal of the Neurological Sciences 2008;273(1-2):10-14
KH Park, SW Kim, DJ Shin, HM Park, YB Lee, YH Seung. A Case of Posterior Cortical Atrophy Presenting with Features of Atypical Dementia. Korean Journal of Biological Psychiatry 2008;15(1):46-53
The Effects of Group Art Therapy on the Visuospatial Ability of the Patients with Dementia of the Alzheimer1s Type. Korean Journal of Art Therapy 2008;15(3):609-625
JH Kim, DJ Shin, HM Park, KH Park, YH Seong, TY Kim, SH Kim, EK Lim, YB Lee. Relations to Plasma Fibrinogen Concentration and Subtype and Prognostic Influence in Patients with Acute Ischemic Stroke. Kor J Cerebrovascular Surgery 2007;9(4):259-264
TY Kim, JH Kim, SH Kim, EK Lim, KH Park, YH Sung, HM Park, DJ Shin, YB Lee. The Relationship Between Serum Triglyceride Level and Clinical Outcome in Patients with Acute Ischemic Stroke. Kor J Cerebrovascular Surgery 2007;9(3):183-187
TY Kim, JH Kim, EK Im, SH Kim, DJ Shin, YB Lee. A Case of Meralgia Paresthetica Caused by Huge Renal Cyst. J Korean Society for Clinical Neurophysiology 2007;9(1):33-35
SH Jeon, DC Han, SG Lee, DJ Shin, HM Park, YB Lee. Eikinella Corrodens Cervical Spinal Epidural Abscess Induced by a Fish Bone. Korean J of Medicine 2007;22(2):380-382
TY Kim, DJ Shin, JH Kim, YB Lee. The Significance of Carotid Intima-Media Thickness in Acute Ischemic Stroke Patients with a Latent Syphilis. J Korean Neurol Assoc 2007;25(1):64-69
DC Han, TY Kim, DJ Shin, HM Park, CW Park, YB Lee. The Comparative Analysis of the Carotid Intima-Media Thickness and Homocysteine Level between Ischemic Stroke and Hypertensive Intracerebral Hemorrhage. Kor J Cerebrovascular Surgery 2006;8(3):190-194
DC Han, YB Lee, DJ Shin. A Case of Myasthenia Gravis associated with Recurrent Transeverse Myelitis. J Korean Neurol Assoc 2007;25(2):244-246
YH Sung, DJ Shin, HM Park, YB Lee, KH Park. Acute Reactive Protein in the Cerebral Small-vessel Occlusion. Kor J Stroke 2006;8(2):187-190
DC Han, HM Park, DJ Shin, YB Lee. A Sensorimotor Polyneuropathy caused by Chronic Phenytoin Therapy. J Korean Society of Clinical Toxicology 2006;4(2):128-130
YH Sung, DJ Shin, HM Park, YB Lee, KH Park. Acute Reactive Protein in the Cerebral Small-vessel Occlusion. Korean J Stroke 2006;8:187-190
DC Han, JH Kim, DJ Shin, HM Park, YB Lee. Suspected Idiopathic Acute Transverse Myelitis: Retrospective Analysis of 27 Cases. J Korean Society for Clinical Neurophysiology 2006;8(1):58-62
SH Kim, DJ Shin, DC Han, HM Park, YB Lee, WC Shin. A Case of Primary Pituitary Lymphoma. J Korean Neurol Assoc 2006;24(2):169-171
SH Ko, YB Lee, KS Kim, HJ Kim, MH Kim, YJ Lee, JH Kim, KW Lee, SH Kim. Role of GSK-3βActivity in Motor Neuronal Cell Death induced by G93A or A4V mutant hSOD1 Gene. European J of Neuroscience 2005;22:301-309
DC Han, YB Lee, DJ Shin. Persistent Trigeminal Artery: an Unusual Cause of Cerebral Infarction. Kor J Cerebrovascular Surgery 2005;7(2):1-3
SH Jeon, DJ Shin, DC Han, HM Park, YB Lee, WC Shin. Bilateral Posterior Ischemic Optic Neuropathy associated with Hemodialysis in a Patient with Chronic Renal Failure. J Korean Neurol Assoc 2005;23(5):703-705
JH Park, YB Lee. A Case of Myasthenia Gravis Associated with Hashimoto`s Thyroiditis. J Korean Neurol Assoc 2005;23(5):700-702
YB Lee, SH Jeon, DC Han, DJ Shin. A Case of IgAλ Monoclonal Gammopathy of Undetermined Significance Mimicking Acute Inflammatory Demyelinating Polyradiculoneuropathy. J Korean Society for Clinical Neurophysiology 2005;7(1):17-19
KS Park, YB Lee, HJ Roh. Clinical Scales for Myasthenia Gravis. J Korean Neurol Assoc 2005;23(s2):104-109
JH Park, DJ Shin, HM Park, YB Lee, WC Shin. Association between Metabolic Syndrome and Plasma Homocysteine Level in Patients with Ischemic Stroke. J Korean Neurol Assoc 2005;23(1):9-14
SH Jeon, YB Kim, YB Lee, JH Park, WC Shin, HM Park, DJ Shin. Sensorimotor Polyneuropathy and Multiple Cranial Neuropathies Associted with IgGκ Monoclonal Gammopathy of Undetermined Significance. J Korean Society for Clinical Neurophysiology 2004;6(1):48-51
YB Lee, DJ Shin. The Effect of Lercanidipine on the Hypertensive Patients with Cerebrovascular Disease. Medical Progress 2004;26(4):84-89
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DC Han, JH Park, WC Shin, YB Lee, HM Park, DJ Shin. A Case of Herpes Zoster Meningitis with Involving Multiple Dermatomes. J Korean Geriatircs Society 2004;8(1):40-42
YC Ko, YB Lee, DJ Shin. A Case of Pineoblastoma with Psychotic Symptoms and Memory Impairment. Gachon Medical J 2004;4(2):317-322
YC Ko, YB Lee, HM Park, DJ Shin. Hemiplegia in Pure Medullary Pyramidal Infarction. Gachon Medical J 2004;4(2):23-28
JH Park, YB Lee, DJ Shin. Risk Factors and Significance of Cerebral White Matter Change in Patients with Stroke. Gachon Medical J 2004;4(2):323-340
YB Kim, YB Lee, DJ Shin. Midbrain Tuberculoma with Oculomotor Palsy. Gachon Medical J 2004;4(2):311-316
ES Choi, YB Lee, HM Park, DJ Shin. The Construction and the Evaluation of Web Sites on Epilepsy Information. Gachon Medical J 2004;4(2):81-98
YB Lee, DJ Shin, SH Kim, JH Kim, MH Kim. Treatment of Myasthenia Gravis in Korea. Gachon Medical J 2004;4(2):293-305
JH Park, HC Choi, WC Shin, YB Lee, HM Park, DJ Shin. Status Epilepticus Precipitated by Intrathecal Injection of Ionic, Hyperosmolar Contrast Agent. Gachon Medical J 2004;4(1):83-90
YB Kim, YC Ko, SH Jeon, HM Park, WC Shin, YB Lee, KS Ha, DJ Shin, YH Yim, JS Ryu, MS Jeong. Toxocariasis: An Unusual Cause of Cerebral Infarction. J Korean Neurol Assoc 2003;21(6):651-654
YC Ko, YB Lee, YB Kim, CJ You, WC Shin, HM Park, KS Ha, DJ Shin. Temporal Relationship between Symptomatic and Electrophysiological Improvement to Postoperative Carpal Tunnel Syndrome Patients: Preliminary Study. J Korean Society for Clinical Neurophysiology 2003;5(2):177-180
HM Park, SS Kang, YB Lee, DJ Shin, ON Kim, SB Lee, DS Yim. Population Pharmacokinetics of Intravenous Valproic Acid in Korean Patients. Journal of Clinical Pharmacy and Therapeutics 2002;27:419-425
YC Ko, SS Kang, YB Lee, HM Park, DJ Shin. Amyotrophic Lateral Sclerosis Combined with Hashimoto`s Thyroiditis: A Case Report. J Korean Society for Clinical Neurophysiology 2001;3(1):37-39
YB Lee, SS Kang, HM Park, DJ Shin. Carotid Artery Intima-Media Thickness and Large-Artery Atherosclerotic Cerebral Infarction. J Korean Neurol Assoc 2001;19(6):573-578
JS Yim, YB Lee, KY Lee, WK Park, YJ Lee, HT Kim, SH Kim, JH Kim, MH Kim. A Case of Chordoma Arising from Clivus. J Korean Neurol Assoc 1999;17(6):908-911
KH Hong, SH Kim, YB Lee, YJ Lee, HT Kim, JH Kim, MH Kim. A Case of Acute Motor Axonal Neuropathy Associated with IgG GM1 Antibody and Campylobacter Jejuni. J Korean Neurol Assoc 1997;15(5):1097-1101
YB Lee, YJ Lee, HT Kim, SH Kim, JH Kim, MH Kim. Outcome after Medical Treatment for Hypertensive Intracerebral Hemorrhage. J Korean Neurol Assoc 1997;15(4):745-753
OY Kwon, YB Lee, BH Yim, KY Lee, HT Kim, SH Kim, JH Kim, MH Kim. Clinical and Radiological Evaluation of Metastatic Brain Tumor. J Korean Neurol Assoc 1996;14(4):965-973
KH Hong, YB Lee, YJ Lee, HT Kim, SH Kim, JH Kim, MH Kim. A Case of Temporal Bone Fibrous Dysplasia Causing Central Venous Thrombosis and Intracranial Hypertension. J Korean Neurol Assoc 1997;15(2):448-453
YB Lee, SH Kim, HT Kim, JH Kim, MH Kim, Y Ko. Jugular Foramen Neurilemmoma Mimicking an Intra-Axial Brainstem Tumor. Korean J of Medicine 1996;11(3):282-284
YB Lee, KH Hong, MK Kim, HT Kim, SH Kim, JH Kim, MH Kim. The Effect of Whole Body Irradiation for the Treatment of Myasthenia Gravis. J Korean Neurol Assoc 1996;14(1):197-205


• Goals

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Contributing to a more specific diagnosis using newly advanced imaging techniques and examining the potential relevance of early detection of stroke using ultra-high-field 7T MRI imaging for the cerebral microcirculation and collateral vessels of cerebral vascular disease in the future.
Observing the early cerebral microvasculature in acute ischemic stroke patients through microvascular imaging studies and maximizing a prognosis of patients through prescribing the correct treatment step.
Conducting the quantitative analysis to reveal the mechanism of cerebrovascular disease using three-dimensional microvascular segmentation technique.


• Researchers

Chang Ki Kang, PhD : ckkang@gachon.ac.kr
Nambeom Kim, PhD : nbumkim@gmail.com


• Co-Researchers

Chan A Park, PhD : capark@gachon.ac.kr


• Collaborators

Dong Hoon Shin, MD, PhD : drshindh@gilhospital.com
Hanul Park, MD, PhD : neurhanulpark@gmail.com


• Research coordinator

Ju Eun young: dud1205@daum.net