• HRRT PET - Installed in 2005 at NRI
Despite its slow but continuous contribution to the field of neuroscience over the past 20 years, recently PET (Position Emission Tomography) has exhibited an accelerated growth due to the emergence of fMRI. The advancement of neuroscience also provided an opportunity for PET, which has unique neuromolecular imaging capability, to advance to its next level of development in conjunction with ultra high field MRI which provides unprecedented spatial resolution.
One of the elements that kept PET from advancing was its low sensitivity and resolution. But at the dawn of the new millennium, brain imaging dedicated PET began to provide high resolution imaging suitable for brain imaging. In 2003, CPS, an American company, finally introduced a prototype PET for brain research purposes, known as HRRT (High Resolution Research Tomography). CPS further developed this prototype system in collaboration with several world-renowned PET research centers, such as Johns Hopkins, Emory, NIH, and UC Irvine in the U.S., the Max Planck Research Center in Germany, and the Neuroscience Research Institute of Gachon University of Medicine and Science in Korea. As a result, reconstruction algorithm has been improved an order of magnitude, among others, let HRRT as a work horse for the neuroscience research.
HRRT is considered to be the most advanced PET of its kind and enables the study of the neurochemistry of human brain with utmost resolution. The resolution of HRRT successfully improved the resolution from the conventional 5–6 mm to the range of 2.5 mm, which has long been considered unattainable. This advancement enabled finally neuroscientists to explore many new areas that were previously thought to be non-explorable.
• Performance Assessment of HRRT - The Highest Resolution Brain-dedicated PET
The operation of the HRRT system has been steadly improved and now deliver a resolution of 2.3 mm, which is the highest available resolution in the PET field. The performance of the HRRT-PET system was assessed by comparing it to the Biograph PET/CT system, which is currently used in clinics. Results of both resolution phantom and human head phantom and finally the human head are shown in the images below.
(Hoffman Phantom and Human Brain Data)