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교수개별소개

Profiles of Faculty

임상뇌과학연구부

Division of Clinical Neuroscience
노영 Young NOH
소속 (Affiliation)
가천대 의과대학 신경과학 (Dept. of Neurology, Gachon Univ. College of Medicine)
직위 (Position)
부교수 (Associate Professor)
센터명 (Center)
임상뇌과학연구부 치매파킨슨병연구센터 (Dementia & Parkinson Disease at Division of Clinical Neuroscience)
실험실 (Lab)
퇴행성 뇌질환 영상 연구실 (Imaging study for Neurodegenerative DIsorder (INDI lab])
연구실위치 (Location)
가천대학교 의과대학 615호 ()
key words of Research
퇴행성 뇌질환, 노화, 분자영상 (degenerative brain diseases, MRI, PE)
  • 032-460-3346
  • ynoh@gilhospital.com
학력 및 경력 (education & experience)

     

2006  MD서울대학교 의과대학 의학사
2013 Final School: MD, PhD 서울대학교 의과대학 신경과학 
2006-2007  서울대학교병원 수련의
2007-2011 서울대학교병원 신경과 전공의
2011  신경과 전문의 취득
2011-2013  삼성서울병원 신경과 임상강사 (치매 및 인지신경학 전공)
2013-2015  가천대 길병원 신경과 임상조교수
2015-2020  가천대학교 의과대학 신경과 조교수
2020-현재 가천대학교 의과대학 신경과 부교수
2015-현재  가천대학교 뇌과학연구원 치매-파킨슨센터 센터장

 

 

연구 소개 (Research in brief)

 

퇴행성 뇌질환 영상 연구실에서는 알츠하이머형 인지장애, 피질하 허혈성 인지장애, 전두측엽 치매 와 같은 퇴행성 치매 질환에서 MRI 와 PET 을 이용한 영상 연구를 수행하고 있다. 임상적으로 진단된 환자를 대상으로MRI 를 이용한 구조 영상과 PET 을 이용한 분자 영상을 획득하고 영상 분석을 통해 영상 바이오마커를 발굴, 평가하는 연구를 심층적으로 하고 있다. 또한, 뇌과학연구원의 초고자장 MRI, 다핵종 MRI 및 고해상도 PET를 비롯한 high technology 를 이용한 임상 연구를 수행하고 있으며, 유전체 분석을 결합한 imaging-genomics 연구에 착수하였다. 우리 연구실에서는 영상 분석을 통하여 치매 질환의 병태생리학적 기전을 밝히며, 퇴행성 뇌질환의 조기 진단 및 치료 효과 판정에 도움이 될 수 있는 민감도와 특이도가 높은 영상 바이오마커를 개발하여 궁극적으로는 환자 치료에 도움이 되는 결과를 도출하는 것을 목표로 하고 있다.

 

INDI(Imaging Study for Neurodegenerative Disorder) lab conducts imaging studies using MRI and PET on degenerative dementia diseases such as Alzheimer's type cognitive disorder, cortical ischemic cognitive disorder and frontal lobe dementia. In-depth research targeting  clinically diagnosed patients is conducted, which is to acquire structural images using MRI and molecular images using PET from the patients and to discover and evaluate biomarkers by the analysis of the patient images obtained. To this end, we are using NRI’s high-tech imaging equipment such as ultra-magnetic MRI, polyatomic MRI and high-resolution PET. Recently, we have undertaken an imaging-genomics study that combines genetic analysis to the images. In summary, my Lab’s final goal is to reveal pathogenetic mechanisms of dementia disease and to develop image biomarkers with high sensitivity and specificity that enable early diagnosis and objectively correct evaluation of treatment effects of degenerative brain diseases.


 

키워드(Key W of Research Field)

 

 

퇴행성 뇌질환, 노화, 분자영상
(degenerative brain diseases, aging, MRI, PET)

 


 Recent Publication (2013 – Present)

 

* KimH, Cho J, Isehunwa O, Noh J, Noh Y, Oh SS, Koh SB, Kim C. Marriage as asocial tie in the relation of depressive symptoms attributable to air pollutionexposure among the elderly. J Affect Disord. 2020 Jul 1;272:125-131.
* NohY , Ahn HY,Hwang IC. Height Loss Is Associated With Suicidal Ideation in Korean Men. Am JGeriatr Psychiatry. 2020 Jul;28(7):798-799.
* JeongHJ, Lee H, Lee SY, Seo S, Park KH, Lee YB, Shin DJ, Kang JM, Yeon BK, Kang SG,Cho J, Seong JK, Okamura N, Villemagne VL, Na DL, Noh Y. [¹⁸ F]THK5351PET Imaging in Patients with Mild Cognitive Impairment. J Clin Neurol. 2020Apr;16(2):202-214.
* JiMJ, Jung S, Seo HE, Kim SY, Kim WR, Kim S, Lee JS, Noh Y. HeterozygousTREM2 Mutation in Semantic Variant of Primary Progressive Aphasia. J ClinNeurol. 2020 Apr;16(2):352-354.
* KimH, Noh J, Noh Y, Oh SS, Koh SB, Kim C. Gender Difference in the Effectsof Outdoor Air Pollution on Cognitive Function Among Elderly in Korea. FrontPublic Health. 2019 Dec 10;7:375.
* JeongHJ, Yoon CW, Seo S, Lee SY, Suh MK, Seo HE, Kim WR, Lee H, Heo JH, Lee YB, ParkKH, Choi SH, Ido T, Lee KM, Noh Y. Relationships between [¹⁸ F]-THK5351Retention and Language Functions in Primary Progressive Aphasia. J Clin Neurol.2019 Oct;15(4):527-536.
* JeonS, Kang JM, Seo S, Jeong HJ, Funck T, Lee SY, Park KH, Lee YB, Yeon BK, Ido T,Okamura N, Evans AC, Na DL, Noh Y. Topographical Heterogeneity ofAlzheimer's Disease Based on MR Imaging, Tau PET, and Amyloid PET. Front AgingNeurosci. 2019 Aug 20;11:211.
* KimKN, Hernandez D, Seo JH, Noh Y, Han Y, Ryu YC, Chung JY. Quantitativeassessment of phased array coils with different numbers of receiving channelsin terms of signal-to-noise ratio and spatial noise variation in magneticresonance imaging. PLoS One. 2019 Jul 5;14(7):e0219407.
* SungYH, Lee J, Nam Y, Shin HG, Noh Y, Hwang KH, Lee H, Kim EY. Initialdiagnostic workup of parkinsonism: Dopamine transporter positron emissiontomography versus susceptibility map-weighted imaging at 3T. Parkinsonism RelatDisord. 2019 May;62:171-178.
* JangH, Park JY, Jang YK, Kim HJ, Lee JS, Na DL, Noh Y, Lockhart SN, SeongJK, Seo SW. Distinct amyloid distribution patterns in amyloid positivesubcortical vascular cognitive impairment. Sci Rep. 2018 Nov 1;8(1):16178.
* KimSE, Woo S, Kim SW, Chin J, Kim HJ, Lee BI, Park J, Park KW, Kang DY, Noh Y,Ye BS, Yoo HS, Lee JS, Kim Y, Kim SJ, Cho SH, Na DL, Lockhart SN, Jang H, SeoSW. A Nomogram for Predicting Amyloid PET Positivity in Amnestic Mild CognitiveImpairment. J Alzheimers Dis. 2018;66(2):681-691.
* ChoiEJ, Son YD, Noh Y, Lee H, Kim YB, Park KH. Glucose Hypometabolism inHippocampal Subdivisions in Alzheimer's Disease: A Pilot Study UsingHigh-Resolution ¹⁸ F-FDG PET and 7.0-T MRI. J ClinNeurol. 2018 Apr;14(2):158-164.
* LeeH, Seo S, Lee SY, Jeong HJ, Woo SH, Lee KM, Lee YB, Park KH, Heo JH, Yoon CW,Kang JM, Cho J, Okamura N, Furumoto S, Yanai K, Na DL, Ido T, Villemagne VL, NohY. [18F]-THK5351 PET Imaging in Patients With Semantic Variant PrimaryProgressive Aphasia. Alzheimer Dis Assoc Disord. 2018 Jan-Mar;32(1):62-69.
* KimEY, Sung YH, Shin HG, Noh Y, Nam Y, Lee J. Diagnosis of Early-StageIdiopathic Parkinson's Disease Using High-Resolution QuantitativeSusceptibility Mapping Combined with Histogram Analysis in the Substantia Nigraat 3 T. J Clin Neurol. 2018 Jan;14(1):90-97.
* SungYH, Lee J, Nam Y, Shin HG, Noh Y, Shin DH, Kim EY. Differentialinvolvement of nigral subregions in idiopathic parkinson's disease. Hum BrainMapp. 2018 Jan;39(1):542-553.
* KangJM, Lee SY, Seo S, Jeong HJ, Woo SH, Lee H, Lee YB, Yeon BK, Shin DH, Park KH,Kang H, Okamura N, Furumoto S, Yanai K, Villemagne VL, Seong JK, Na DL, Ido T,Cho J, Lee KM, Noh Y. Tau positron emission tomography using[18F]THK5351 and cerebral glucose hypometabolism in Alzheimer's disease. NeurobiolAging. 2017 Nov;59:210-219.
* ParkKH, Noh Y, Choi EJ, Kim H, Chun S, Son YD. Functional Connectivity ofthe Hippocampus in Early- and vs. Late-Onset Alzheimer's Disease. J ClinNeurol. 2017 Oct;13(4):387-393.
* NaHK, Kang DR, Kim S, Seo SW, Heilman KM, Noh Y, Na DL. Malignantprogression in parietal-dominant atrophy subtype of Alzheimer's disease occursindependent of onset age. Neurobiol Aging. 2016 Nov;47:149-156.
* NohY , Seo SW,Jeon S, Lee JM, Kim JS, Lee JH, Kim JH, Kim GH, Ye BS, Cho H, Kim HJ, Yoon CW,Choe YS, Lee KH, Weiner MW, Na DL. The role of cerebrovascular disease inamyloid deposition. J Alzheimers Dis. 2016 Oct 4;54(3):1015-1026.
* KimEY, Shin DH, Noh Y, Goh BH, Lee YB. Comparison of Imaging SelectionCriteria for Intra-Arterial Thrombectomy in Acute Ischemic Stroke with AdvancedCT. Eur Radiol. 2016 Sep;26(9):2974-81.
* KimGH, Im K, Kwon H, Seo SW, Ye BS, Cho H, Noh Y, Lee JM, Kim ST, Park SE,Kim H, Hwang JW, Kang SJ, Jeong JH, Na DL. Higher Physical Activity IsAssociated with Increased Attentional Network Connectivity in the HealthyElderly. Front Aging Neurosci. 2016 Aug 22;8:198.
* SungYH, Noh Y, Lee J, Kim EY. Drug-induced parkinsonism versus idiopathic parkinsondisease: Utility of Nigrosome 1 with 3-T imaging. Radiology. 2016Jun;279(3):849-58.
* NohY , Jung CK,Hong JH, Jeong JH, Chang JY, Kim BJ, Bae HJ, Kwon OK, Oh CW, Han MK.Recanalization rate and clinical outcome in acute carotid-T occlusion. Eur Neurol.2015;74(1-2):36-42.
* NohY , Sung YH,Lee J, Kim EY. Nigrosome 1 Detection at 3T MRI for the Diagnosis of Early-StageIdiopathic Parkinson Disease: Assessment of Diagnostic Accuracy and Agreementon Imaging Asymmetry and Clinical Laterality. AJNR Am J Neuroradiol. 2015Nov;36(11):2010-6.
* YeBS, Seo SW, Kim JH, Kim GH, Cho H, Noh Y, Kim HJ, Yoon CW, Woo SY, KimSH, Park HK, Kim ST, Choe YS, Lee KH, Kim JS, Oh SJ, Kim C, Weiner M, Lee JH,Na DL. Effects of amyloid and vascular markers on cognitive decline insubcortical vascular dementia. Neurology.2015 Nov 10;85(19):1687-93.
* KimHJ, Im K, Kwon H, Lee JM, Kim C, Kim YJ, Jung NY, Cho H, Ye BS, Noh Y,Kim GH, Ko ED, Kim JS, Choe YS, Lee KH, Kim ST, Lee JH, Ewers M, Weiner MW, NaDL, Seo SW. Clinical effect of white matter network disruption related toamyloid and small vessel disease. Neurology. 2015 Jul 7;85(1):63-70.
* YeBS, Seo SW, Kim GH, Noh Y, Cho H, Yoon CW, Kim HJ, Chin J, Jeon S, LeeJM, Seong JK, Kim JS, Lee JH, Choe YS, Lee KH, Sohn YH, Ewers M, Weiner M, NaDL. Amyloid burden, cerebrovascular disease, brain atrophy, and cognition incognitively impaired patients. Alzheimers Dement. 2015 May;11(5):494-503.e3.
* KimGH, Jeon S, Im K, Kwon H, Lee BH, Kim GY, Jeong H, Han NE, Seo SW, Cho H, NohY, Park SE, Kim H, Hwang JW, Yoon CW, Kim HJ, Ye BS, Chin JH, Kim JH, SuhMK, Lee JM, Kim ST, Choi MT, Kim MS, Heilman KM, Jeong JH, Na DL. Structuralbrain changes after traditional and robot-assisted multi-domain cognitivetraining in community-dwelling healthy elderly. PLoS One. 2015 Apr21;10(4):e0123251.
* Kim GH,Lee JH, Seo SW, Kim JH, Seong JK, Ye BS, Cho H, Noh Y, Kim HJ, Yoon CW,Oh SJ, Kim JS, Choe YS, Lee KH, Kim ST, Hwang JW, Jeong JH, Na DL. Hippocampalvolume and shape in pure subcortical vascular dementia. Neurobiol Aging. 2015Jan;36(1):485-91.
* KimH, Kim C, Seo SW, Na DL, Kim HJ, Kang M, Shin HY, Cho SK, Park SE, Lee J, HwangJW, Jeon S, Lee JM, Kim GH, Cho H, Ye BS, Noh Y, Yoon CW, Guallar E. Association between body mass index and corticalthickness: among elderly cognitively normal men and women.Int Psychogeriatr. 2015Jan;27(1):121-30.
* ChoH, Jeon S, Kim C, Ye BS, Kim GH, Noh Y, Kim HJ, Yoon CW, Kim YJ, Kim JH,Park SE, Kim ST, Lee JM, Kang SJ, Suh MK, Chin J, Na DL, Kang DR, Seo SW. Higher education affects accelerated cortical thinning inAlzheimer's disease: a 5-year preliminary longitudinal study.Int Psychogeriatr. 2015Jan;27(1):111-20.
* Noh Y , Jeon S, Lee JM, Seo SW, Kim GH, Cho H, YeBS, Yoon CW, Kim HJ, Chin J, Park KH, Heilman KM, Na DL. Anatomicalheterogeneity of Alzheimer disease: based on cortical thickness on MRIs.Neurology. 2014 Nov 18;83(21):1936-44.
* Noh Y , Seo SW, Jeon S, Lee JM, Kim JH, Kim GH,Cho H, Yoon CW, Kim HJ, Ye BS, Kim ST, Choe YS, Lee KH, Kim JS, Ewers M, WeinerMW, Lee JH, Werring DJ, Kang DR, Kim CS, Na DL. White matter hyperintensitiesare associated with amyloid burden in APOE4 non-carriers. J Alzheimers Dis.2014;40(4):877-86.
* Yoon CW, Kang M, Shin HY, Jeon S, Yang JJ,Kim ST, Noh Y, Kim GH, Kim HJ, Kim YJ, Kim JH, Cho H, Ye BS, Lee JM,Choi SH, Im K, Moon HS, Na DL, Seo SW. Higher C-peptide levels are associatedwith regional cortical thinning in 1093 cognitively normal subjects. Eur JNeurol. 2014 Oct;21(10):1318-23, e80-1.
* Noh HJ, Seo SW, Jeong Y, Park JE, Kim GH, Noh Y,Cho H, Kim HJ, Yoon CW, Ye BS, Werring DJ, Na DL. Blood Viscosity inSubcortical Vascular Mild Cognitive Impairment with versus without CerebralAmyloid Burden. J Stroke Cerebrovasc Dis. 2014 May-Jun;23(5):958-66.
* Kim HJ, Ye BS, Yoon CW, Noh Y, Kim GH, Cho H,Jeon S, Lee JM, Kim JH, Seong JK, Kim CH, Choe YS, Lee KH, Kim ST, Kim JS, ParkSE, Kim JH, Chin J, Cho J, Kim C, Lee JH, Weiner MW, Na DL, Seo SW. Corticalthickness and hippocampal shape in pure vascular mild cognitive impairment anddementia of subcortical type. Eur J Neurol. 2014 May;21(5):744-51.
* Noh Y , Lee Y, Seo SW, Jeong JH, Choi SH, BackJH, Woo SY, Kim GH, Shin JS, Kim CH, Cho H, Park JS, Lee JM, Hong CH, Kim SY,Lee JH, Kim SY, Park KH, Han SH, Cheong HK, Na DL. A New Classification Systemfor Ischemia using a Combination of Deep and Periventricular White MatterHyperintensities. J Stroke Cerebrovasc Dis. 2014 Apr;23(4):636-42.
Kim GH, Lee JH, Seo SW, Ye BS, Cho H, KimHJ, Noh Y, Yoon CW, Chin JH, Oh SJ, Kim JS, Choe YS, Lee KH, Kim ST, JeongJH, Na DL. Seoul criteria for PiB(-) subcortical vascular dementia based onclinical and MRI variables. Neurology. 2014 Apr 29;82(17):1529-35.
* Lee MJ, Seo SW, Na DL, Kim C, Park JH, Kim GH, KimCH, Noh Y, Cho H, Kim HJ, Yoon CW, Ye BS, Chin J, Jeon S, Lee JM, ChoeYS, Lee KH, Kim JS, Kim ST, Lee JH, Ewers M, Werring DJ, Weiner MW. SynergisticEffects of Ischemia and * Ye BS, Seo SW, Kim CH, Jeon S, Kim GH, Noh Y,Cho H, Yoon CW, Kim HJ, Jang EY, Lee J, Kim JH, Chin J, Lee JM, Kim JH, SeongJK, Kim CH, Choe YS, Lee KH, Na DL. Hippocampal and cortical atrophy inamyloid-negative mild cognitive impairments: comparison with amyloid-positivemild cognitive impairment. Neurobiol Aging. 2014 Feb;35(2):291-300.
* Ye BS, Seo SW, Yang JJ, Kim HJ, Kim YJ, Yoon CW, ChoH, Noh Y, Kim GH, Chin J, Kim JH, Jeon S, Lee JM, Na DL. Comparison ofcortical thickness in patients with early-stage versus late-stage amnestic mildcognitive impairment. Eur J Neurol. 2014;21(1):86-92.
* ParkJH, Seo SW, Kim C, Kim SH, Kim GH, Kim ST, Jeon S, Lee JM, Oh SJ, Kim JS, ChoeYS, Lee KH, Shin JS, Kim CH, Noh Y,Cho H, Yoon CW, Kim HJ, Ye BS, Ewers M, Weiner MW, Lee JH, Werring DJ, Na DL. Effects of cerebrovasculardisease and amyloid beta burden on cognition in subjects with subcorticalvascular cognitive impairment. Neurobiol Aging 2014 Jan;35(1):254-60.
* KimHJ, Ye BS, Yoon CW, Cho H, Noh Y,Kim GH, Choi YS, Kim JH, Jeon S, Lee JM, Kim JS, Choe YS, Lee KH, Kim ST, KimC, Kang DR, Ki CS, Lee JH, Werring DJ, Weiner MW, Na DL, Seo SW. Effects of APOE ε4on brain amyloid, lacunar infarcts, and white matter lesions: astudyamong patients with subcortical vascular cognitive impairment.Neurobiol Aging.2013 Nov;34(11):2482-7.
* ChoH, Seo SW, Kim JH, Suh MK, Lee JH, Choe YS, Lee KH, Kim JS, Kim GH, Noh Y, Ye BS, Kim HJ, Yoon CW,Chin J, Na DL. Amyloid deposition in early onset versus late onsetAlzheimer's disease.J Alzheimers Dis. 2013;35(4):813-21.
* KimHJ, Kang SJ, Kim C, Kim GH, Jeon S, Lee JM, Oh SJ, Kim JS, Choe YS, Lee KH, Noh Y, Cho H, Yoon CW, Chin J,Cummings JL, Lee JH, Na DL, SeoSW. The effects of smallvessel disease and amyloid burden on neuropsychiatric symptoms: a study amongpatients with subcortical vascular cognitive impairments.Neurobiol Aging.2013 Jul;34(7):1913-20.
* ChoH, Seo SW, Kim JH, Kim C, Ye BS, Kim GH, Noh Y, Kim HJ, Yoon CW, Seong JK, Kim CH, Kang SJ, Chin J, KimST, Lee KH, Na DL. Changes insubcortical structures in early- versus late-onset Alzheimer’s disease. Neurobiol Aging. 2013 Jul;34(7):1740-7.
* ChoH, Jeon S, Kang SJ, Lee JM, Lee JH, Kim GH, Shin JS, Kim CH, Noh Y, Im K, Kim ST, Chin J, SeoSW, Na DL. Longitudinal changes of cortical thickness in early-versus late-onset Alzheimer's disease. Neurobiol Aging . 2013 Jul;34(7):1921.e9-1921.e15.
* ParkJH, Seo SW, Kim C, Kim GH, Noh HJ, Kim ST, Kwak KC, Yoon U, Lee JM, Lee JW,Shin JS, Kim CH, Noh Y,Cho H, Kim HJ, Yoon CW, Oh SJ, Kim JS, Choe YS, Lee KH, Lee JH, Ewers M, WeinerMW, Werring DJ, Na DL. Pathogenesis of cerebral microbleeds: In vivo imaging ofamyloid and subcortical ischemic small vessel disease in 226 individuals withcognitive impairment.Ann Neurol. 2013 May;73(5):584-93.
* Yoon CW, Shin JS, Kim HJ, Cho H, Noh Y, Kim GH, Chin JH, Oh SJ, Kim JS, Choe YS, Lee KH, Lee JH, Seo SW, Na DL.Cognitive deficits of pure subcortical vascular dementia vs Alzheimer disease: PiB-PET-based study. Neurology. 2013 Feb 5;80(6):569-73.
* Cho EB, Seo SW, Kim H, Lee JM, Yoon U, Im K, Kim GH, Noh Y, Cho H, Yoon CW, Kim HJ, Na DL. Effect of Kidney Dysfunction on Cortical Thinning in Patients with Probable Alzheimer's Disease Dementia. J Alzheimers Dis. 2013;33(4):961-8.
* YoonCW, Seo SW, Park JS, Kwak KC, Yoon U, Suh MK, Kim GH, Shin JS, Kim CH, Noh Y,Cho H, Kim MJ, Kim JH, Roh JH, Lee JM, Na DL. Cerebellar atrophy in patientswith subcortical-type vascular cognitive impairment. Cerebellum.2013 Feb;12(1):35-42.
* Noh Y , Kim DW, Chu K, Lee ST, Jung KH,Moon HJ, Lee SK. Topiramateincreases the risk of valproic acid-induced encephalopathy. Epilepsia. 2013Jan;54(1):e1-4.