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대학원

Education

대학원

Education
장근아 Keun-A CHANG
소속 (Affiliation)
가천대 의과대학 약리학교실/이길 여 암·당뇨연구원 (Dept. of Pharmacology Gachon Univ.College of Medicine/Gachon Univ. Lee Gil Ya Cancer and Diabetes Re)
직위 (Position)
부교수 (Associate Professor)
센터명 (Center)
기초뇌과학연구부 부장 및 정서인지연구센터 (Division of Basic Neuroscience, Research Center for Cognition & Emotion)
실험실 (Lab)
뉴로랩 (NEURO)
연구실위치 (Location)
가천대 이길여 암당뇨연구원 연구동 N404호 ()
key words of Research
퇴행성뇌질환, 학습-기억, 뇌인지, 우울증, 신경회로망 (neurodegenerative diseases, learning & memory, brain cognition, depression, neural circuit)
  • 032-899-6411
  • keuna705@gachon.ac.kr
학력 및 경력 (education & experience)

     

2004 Final School: PhD 서울대학교 의과대학 약리학 (Dept of Pharmacology, Seoul National Univ. College of Medicine)
2004-2008 선임연구원, 서울대학교 의과대학, 신경과학연구소
2009-2012 책임연구원, 서울대학교 의과대학, 신경과학연구소
2012-현재 부교수, 가천대학교 의과대학

 

 

연구 소개 (Research in brief)

 

뉴로랩 (Neuro Lab) 연구실에서는 알츠하이머 치매를 포함한 퇴행성 뇌질환 치료법의 개발을 주된 목표로 삼고 다양한 수준에서의 신경과학연구를 수행하고 있다. 화학, 약물적 접근 방법뿐만 아니라, 신경 줄기세포 이식 등을 적극 활용하여 퇴행성 뇌질환의 새로운 치료법을 연구하고 있다. 뉴로랩 연구실에서는 인지 신경 행동에 관한 연구도 활발하게 진행하여, 인지와 행동을 조절하는 신경회로망에 대하여 심층적으로 연구하고 있다.

 

My lab is Neuro Lab which is primarily aiming at the development of a therapeutic approach for neurodegenerative diseases including Alzheimer's disease and Parkinson’s disease. For this purpose, two main approaches are used: one is a pharmacological approach through a screening system to find effective chemicals and the other is a biological approach using stem cells or optogenetics. Also, the Neuro Lab is conducting actively the study on behavior and cognition, particularly in-depth research into neural circuit networks that control perception and behavior.
 

 

키워드(Key W of Research Field)

 

 

퇴행성뇌질환, 학습-기억, 정서-인지, 우울증, 신경회로망
(neurodegenerative disease, learning & memory, emotion & cognition, depression, neural circuit)

 


 Recent Publication (2013 – Present)

 

1. Park H, Kang S, Nam E, Suh YH, Chang KA. (2019) The Protective Effects of PSM-04 Against Beta Amyloid-Induced Neurotoxicity in Primary Cortical Neurons and an Animal Model of Alzheimer's Disease. Front Pharmacol. 2019 Jan 24;10:2. doi: 10.3389/fphar.2019.00002. eCollection 2019.
2. Kang S, Ha S, Park H, Nam E, Suh WH, Suh YH, Chang KA. (2018) Effects of a Dehydroevodiamine-Derivative on Synaptic Destabilization and Memory Impairment in the 5xFAD, Alzheimer's Disease Mouse Model. Front Behav Neurosci. 2018 Nov 13;12:273. doi: 10.3389/fnbeh.2018.00273. ECollection 2018.
3. Kwon YD, Kang S, Park H, Cheong IK, Chang KA, Lee SY, Jung JH, Lee BC, Lim ST, Kim HK (2018) Novel potential pyrazolopyrimidine based translocator protein ligands for the evaluation of neuroinflammation with PET. Eur J Med Chem. 2018 Nov 5;159:292-306. doi: 10.1016/j.ejmech.2018.09.069. Epub 2018 Sep 29
4. Kim JY, Rasheed A, Yoo SJ, Kim SY, Cho B, Son G, Yu SW, Chang KA, Suh YH, Moon C. (2017) Distinct amyloid precursor protein processing machineries of the olfactory system. Biochem Biophys Res Commun. 2018 Jan 1;495(1):533-538.
5. Yoo SJ, Lee JH, Kim SY, Son G, Kim JY, Cho B, Yu SW, Chang KA, Suh YH, Moon C. (2017) Differential spatial expression of peripheral olfactory neuron-derived BACE1 induces olfactory impairment by region-specific accumulation of β-amyloid oligomer. Cell Death Dis. 2017 Aug 10;8(8):e2977.
6. Ha S, Park H, Mahmood U, Ra JC, Suh YH, Chang KA. (2017) Human adipose-derived stem cells ameliorate repetitive behavior, social deficit and anxiety in a VPA-induced autism mouse model. Behav Brain Res. 2017 Jan 15;317:479-484.
7. Jhang KA, Lee EO, Kim HS, Chang KA, Suh YH, Chong YH. (2016) S100A9 Exacerbates the Aβ1-42-mediated Innate Immunity in Human THP-1 Monocytes. CNS Neurol Disord Drug Targets. 2016;15(8):910-917.
8. Shin KY, Noh SJ, Park CH, Jeong YH, Chang KA, Yoo J, Kim HJ, Ha S, Kim HS, Park HJ, Lee JH, Moon C, Suh YH. (2016) Dehydroevodiamine•HCl Protects Against Memory Impairment and Cerebral Amyloid-beta Production in Tg2576 Mice by Acting as a beta-Secretase Inhibitor. CNS Neurol Disord Drug Targets. 2016;15(8):935-944.
9. Chang KA, Shin KY, Nam E, Lee YB, Moon C, Suh YH, Lee SH. (2016) Plasma soluble neuregulin-1 as a diagnostic biomarker for Alzheimer's disease. Neurochem Int. 2016 Jul;97:1-7.
10. Choi HS, Kim HJ, Oh JH, Park HG, Ra JC, Chang KA, Suh YH. (2015) Therapeutic potentials of human adipose-derived stem cells on the mouse model of Parkinson's disease. Neurobiol Aging. 2015 Oct;36(10):2885-92.
11. Joo Y, Schumacher B, Landrieu I, Bartel M, Smet-Nocca C, Jang A, Choi HS, Jeon NL, Chang KA, Kim HS, Ottmann C, Suh YH. (2015) Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau. FASEB J. 2015 Oct;29(10):4133-44. doi: 10.1096/fj.14-265009. Epub 2015 Jun 23.