Pain is primarily caused by the specific activation of a number of pain receptors present at the primary afferent nerve endings. Transient receptor potential (TRP) channel family is well known as a typical pain receptor, and attempts are now being made to develop next-generation painkillers using TRP chanels (TRPV1, TRPA1) blockers. In addition, studies are being conducted to control pain by developing drugs that can inhibit the activity of major pain receptors in pain-transmitting nerve cells. Based upon this knowledge, our Lab are trying to identify, at the molecular and cellular levels, various factors contributing to the initiation, transmission, control and hyperalgesia of pain within the pain delivery nerve. Also, we are conducting research at various levels of molecules, single cells, synapses through a comprehensive experiments using a set of techniques used in the electrophysiology, chemistry, cytology, biology, and animal behavior. Final goal is to identify a substance which act on a particular site by a specific mechanism and eventually to develop a new pain control technique using this material.