교수 및 연구진
Faculty
기초뇌과학연구부
Division of Basic Neuroscience
- Profiles of Faculty
- Division of Basic Neuroscience
김용호 Yong Ho KIM
- 소속 (Affiliation)
- 가천대 의과대학 생리학교실/가천 통증 연구소/이길여·암당뇨연구원 (Dept. of Physiology, Gachon Univ. College of Medicine/Gachon Pain Center/Gachon Univ. Lee Gil Ya Can)
- 직위 (Position)
- 조교수 (Assist. Professor)
- 센터명 (Center)
- 기초뇌과학연구부 통증연구센터 (Research Center for Pain at Division of Basic Neuroscience)
- 실험실 (Lab)
- 감각인지 연구실 (SPaC Lab | Sensory Physiology and Cognition)
- 연구실위치 (Location)
- 이길여 암당뇨연구원 S311-1호 ()
- key words of Research
- 통증, 가려움증, 감각이상, 신경-면역 네트워크, 신경가소성, 이온통로, 전기생리학, 동물행동연구 (pain, pruritus, paresthesia, nerve-immunology network, neural plasticity, ion channel, electrophysiology, animal behavior)
- 032-899-6691
- euro16@gachon.ac.kr
￭ 학력 및 경력 (education & experience)
(Pain, Pruritus, Sensory Abnormalities, Neuro-Immune Network, Neuronal Plasticity, Ion Channels, Electrophysiology, Animal Behavior)
2. The Role of Maresins in Inflammatory Pain: Function of Macrophages in Wound Regeneration. Neurosci. Int J Mol Sci. 2019 Nov 21;20(23)
3. Ion Channels Involved in Tooth Pain. Int J Mol Sci. 2019 May 8;20(9).
4. Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via α2-Adrenoceptors in Trigeminal Ganglion Neurons. Mediators Inflamm. 2018 Sep 2;2018:1782719.
5. miRNA-711 binds and activates TRPA1 extracellularly to evoke acute and chronic pruritus. Neuron. 2018 Aug 8:99(3):449-463.
6. Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis. Nature. 2017 Nov 8;551(7679):192-197.
7. Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers. JCI Insight. 2017 Oct 19;2(20).
8. PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1. Nat Neurosci. 2017 Jul;20(7):917-926.
9. SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons. Neuron 2016 Dec 21;92(6):1279-1293.
10. Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. Cell. 2016 Jan 14;164(1-2):183-96.
11. Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade. Nat Med. 2015 Nov;21(11):1326-31.
Final School: PhD. 서울대학교 치과대학 생리학교실
(Dept. of Physiology, Seoul National Univ. School of Dentistry)
2012 이학박사 (신경생리학), 서울대학교
2012-2016 박사 후 연구원, 서울대학교
2012 일본 생리학연구소 방문 연구원
2014 미국 듀크대학교 방문 연구원
2016-현재 조교수, 가천대학교
￭ 연구 소개 (Research in brief)
감각인지 연구실에서는 “체성 감각 및 통각 신호 인지기능”에 관한 연구를 수행 중이다. 본 연구실은 감각 인지 및 조절 연구를 통하여 통증 및 가려움증과 같은 감각이상에 대한 기전을 규명하기 위해 감각의 발생에서부터 행동 (From nociception To pain cognition)에 이르는 감각 인지기능분야까지의 포괄적인 영역을 연구하고자 한다. 이에 본 연구실에서는 감각처리 및 인지과정을 이해하기 위해 감각의 정서적 처리 과정을 포함하는 통섭(通涉)적 접근을 통하여, 말초 및 중추 신경망을 구성하는 신경-신경교세포-면역세포간의 기능과 상호작용의 분자·신경생물학적 기전을 연구하고 있다.
My Lab is Sensory Physiology and Cognition Lab where a study is being conducted on body sensory and cognitive function for pain signal. For this purpose, the Lab is conducting a comprehensive research on sensory cognitive functions ranging from sensory signal generation to behavior (from nociception to pain cognition) in order to identify the mechanisms for sensory abnormalities such as pain and itching through sensory cognitive and control studies. Also this Lab has been studying the molecular mechanisms of functional interactions between neuron-glia-immune cells that make up the peripheral and central neural networks through a comprehensive approach to understanding the emotional process of sensory processing.
￭ 키워드(Key W of Research Field)
통증, 가려움증, 감각이상, 신경-면역 네트워크, 신경가소성, 이온통로, 전기생리학, 동물행동연구
(Pain, Pruritus, Sensory Abnormalities, Neuro-Immune Network, Neuronal Plasticity, Ion Channels, Electrophysiology, Animal Behavior)
￭ Recent Publication (2013 – Present)
1. Elevated TRPV4 Levels Contribute to Endothelial Damage and Scarring in Experimental Spinal Cord Injury. J Neurosci. 2020 Feb 26;40(9):1943-1955.
2. The Role of Maresins in Inflammatory Pain: Function of Macrophages in Wound Regeneration. Neurosci. Int J Mol Sci. 2019 Nov 21;20(23)
3. Ion Channels Involved in Tooth Pain. Int J Mol Sci. 2019 May 8;20(9).
4. Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via α2-Adrenoceptors in Trigeminal Ganglion Neurons. Mediators Inflamm. 2018 Sep 2;2018:1782719.
5. miRNA-711 binds and activates TRPA1 extracellularly to evoke acute and chronic pruritus. Neuron. 2018 Aug 8:99(3):449-463.
6. Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis. Nature. 2017 Nov 8;551(7679):192-197.
7. Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers. JCI Insight. 2017 Oct 19;2(20).
8. PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1. Nat Neurosci. 2017 Jul;20(7):917-926.
9. SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons. Neuron 2016 Dec 21;92(6):1279-1293.
10. Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. Cell. 2016 Jan 14;164(1-2):183-96.
11. Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade. Nat Med. 2015 Nov;21(11):1326-31.