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연구

Research

기초뇌과학연구부

Division of Basic Neuroscience
  • Research
  • Division of Basic Neuroscience
장근아 Keun-A CHANG
소속 (Affiliation)
가천대 의과대학 약리학교실/이길 여 암·당뇨연구원 (Dept. of Pharmacology Gachon Univ.College of Medicine/Gachon Univ. Lee Gil Ya Cancer and Diabetes Re)
직위 (Position)
부교수 (Associate Professor)
센터명 (Center)
기초뇌과학연구부 부장 및 정서인지연구센터 (Division of Basic Neuroscience, Research Center for Cognition & Emotion)
실험실 (Lab)
뉴로랩 (NEURO)
연구실위치 (Location)
가천대 이길여 암당뇨연구원 연구동 N404호 ()
key words of Research
퇴행성뇌질환, 학습-기억, 뇌인지, 우울증, 신경회로망 (neurodegenerative diseases, learning & memory, brain cognition, depression, neural circuit)
  • 032-899-6411
  • keuna705@gachon.ac.kr

￭ 학력 및 경력 (education & experience)

     

2004 Final School: PhD 서울대학교 의과대학 약리학 (Dept of Pharmacology, Seoul National Univ. College of Medicine)
2004-2008 선임연구원, 서울대학교 의과대학, 신경과학연구소
2009-2012 책임연구원, 서울대학교 의과대학, 신경과학연구소
2012-현재 부교수, 가천대학교 의과대학

 

 

￭ 연구 소개 (Research in brief)

 

뉴로랩 (Neuro Lab) 연구실에서는 알츠하이머 치매를 포함한 퇴행성 뇌질환 치료법의 개발을 주된 목표로 삼고 다양한 수준에서의 신경과학연구를 수행하고 있다. 화학, 약물적 접근 방법뿐만 아니라, 신경 줄기세포 이식 등을 적극 활용하여 퇴행성 뇌질환의 새로운 치료법을 연구하고 있다. 뉴로랩 연구실에서는 인지 신경 행동에 관한 연구도 활발하게 진행하여, 인지와 행동을 조절하는 신경회로망에 대하여 심층적으로 연구하고 있다.

 

My lab is Neuro Lab which is primarily aiming at the development of a therapeutic approach for neurodegenerative diseases including Alzheimer's disease and Parkinson’s disease. For this purpose, two main approaches are used: one is a pharmacological approach through a screening system to find effective chemicals and the other is a biological approach using stem cells or optogenetics. Also, the Neuro Lab is conducting actively the study on behavior and cognition, particularly in-depth research into neural circuit networks that control perception and behavior.
 

 

￭ 키워드(Key W of Research Field)

 

 

퇴행성뇌질환, 학습-기억, 정서-인지, 우울증, 신경회로망
(neurodegenerative disease, learning & memory, emotion & cognition, depression, neural circuit)

 


￭ 최근 연구업적(2020-현재)

 

1. Metabotropic glutamate receptor 5 in amygdala target neurons regulates susceptibility to chronic social stress. Biological Psychiatry (2022) S0006-3223(22)00028-2. Online ahead of print. (교신)


2. miR-200c suppression increases tau hyperphosphorylation by targeting 14-3-3γ in early stage of 5xFAD mouse model of Alzheimer's disease (2022) Int J Biol Sci.18(5):2220-2234. (교신)


3. Potential Biomarkers for Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis (2022) Int J Mol Sci. 6;23(2):602. (교신)


4. The potential anti-amyloidogenic candidate, SPA1413, for Alzheimer's disease. Br J Pharmacol. (2022) 179:1033–1048. (교신)


5. Long-Term Treatment of Cuban Policosanol Attenuates Abnormal Oxidative Stress and Inflammatory Response via Amyloid Plaques Reduction in 5xFAD Mice. Antioxidants (Basel). (2021) 10(8):1321 (교신)


6. Brain-Derived Exosomal Proteins as Effective Biomarkers for Alzheimer's Disease: A Systematic Review and Meta-Analysis. Biomolecules. (2021) 11(7):980. (교신)


7. Sex Difference in Peripheral Inflammatory Biomarkers in Drug-Naïve Patients with Major Depression in Young Adulthood. Biomedicines. (2021) 9(7):708. (교신)


8. Spatial memory deficiency early in 6xTg Alzheimer's disease mouse model. Sci Rep. (2021) 11(1):1334. (교신)


9. Interleukin-17 induced by cumulative mild stress promoted depression-like behaviors in young adult mice. Mol Brain. (2021) 14(1):11. (교신)


10. Therapeutic Potential of Magnetic Nanoparticle-Based Human Adipose-Derived Stem Cells in a Mouse Model of Parkinson's Disease. Int J Mol Sci. (2021) 22(2):654. (교신)


11. Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD mice. Alzheimers Res Ther. (2021) 13(1):4. (공동)


12. RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's disease. Neuropathol Appl Neurobiol. (2021) 47(5):625-639. (공동)


13. Therapeutic Potential of Repeated Intravenous Transplantation of Human Adipose-Derived Stem Cells in Subchronic MPTP-Induced Parkinson's Disease Mouse Model. Int J Mol Sci. (2020) 21(21):8129. (교신)


14. Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer's Disease Progression. Int J Mol Sci. (2020) 21(14):5007. (교신)


15. Longitudinal profiling of oligomeric Aβ in human nasal discharge reflecting cognitive decline in probable Alzheimer's disease. Sci Rep. (2020) 10(1):11234. (공동)


16. Therapeutic Effects of Human Amniotic Epithelial Stem Cells in a Transgenic Mouse Model of Alzheimer's Disease. Int J Mol Sci. (2020) 21(7):2658. (교신)